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Design of anti- and pro-aggregation variants to assess the effects of methionine oxidation in human prion protein

Prion disease is characterized by the α→β structural conversion of the cellular prion protein (PrP(C)) into the misfolded and aggregated “scrapie” (PrP(Sc)) isoform. It has been speculated that methionine (Met) oxidation in PrP(C) may have a special role in this process, but has not been detailed an...

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Autori principali: Wolschner, Christina, Giese, Armin, Kretzschmar, Hans A., Huber, Robert, Moroder, Luis, Budisa, Nediljko
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2674404/
https://ncbi.nlm.nih.gov/pubmed/19416900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0902688106
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