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A concise, total synthesis of the TMC-95A/B proteasome inhibitors
A concise, total synthesis of the proteasome inhibitors TMC-95A/B has been accomplished. The synthesis features the use of an l-serine-derived E-selective modified Julia olefination reaction to ultimately control the stereochemical outcome of the highly oxidized tryptophan fragment. Additionally, th...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2004
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC514414/ https://ncbi.nlm.nih.gov/pubmed/15163792 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0308432101 |
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