Th1 cells downregulate connexin 43 gap junctions in astrocytes via microglial activation

We previously reported early and extensive loss of astrocytic connexin 43 (Cx43) in acute demyelinating lesions of multiple sclerosis (MS) patients. Because it is widely accepted that autoimmune T cells initiate MS lesions, we hypothesized that infiltrating T cells affect Cx43 expression in astrocyt...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Watanabe, Mitsuru, Masaki, Katsuhisa, Yamasaki, Ryo, Kawanokuchi, Jun, Takeuchi, Hideyuki, Matsushita, Takuya, Suzumura, Akio, Kira, Jun-ichi
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5143974/
https://ncbi.nlm.nih.gov/pubmed/27929069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep38387
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