Interleukin-1β Induces Blood–Brain Barrier Disruption by Downregulating Sonic Hedgehog in Astrocytes

The blood–brain barrier (BBB) is composed of capillary endothelial cells, pericytes, and perivascular astrocytes, which regulate central nervous system homeostasis. Sonic hedgehog (SHH) released from astrocytes plays an important role in the maintenance of BBB integrity. BBB disruption and microglia...

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Bibliografiske detaljer
Main Authors: Wang, Yue, Jin, Shijie, Sonobe, Yoshifumi, Cheng, Yi, Horiuchi, Hiroshi, Parajuli, Bijay, Kawanokuchi, Jun, Mizuno, Tetsuya, Takeuchi, Hideyuki, Suzumura, Akio
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2014
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196962/
https://ncbi.nlm.nih.gov/pubmed/25313834
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0110024
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