GM-CSF increases LPS-induced production of proinflammatory mediators via upregulation of TLR4 and CD14 in murine microglia

BACKGROUND: Microglia are resident macrophage-like cells in the central nervous system (CNS) and cause innate immune responses via the LPS receptors, Toll-like receptor (TLR) 4 and CD14, in a variety of neuroinflammatory disorders including bacterial infection, Alzheimer’s disease, and amyotrophic l...

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Bibliographic Details
Main Authors: Parajuli, Bijay, Sonobe, Yoshifumi, Kawanokuchi, Jun, Doi, Yukiko, Noda, Mariko, Takeuchi, Hideyuki, Mizuno, Tetsuya, Suzumura, Akio
Format: Artigo
Language:Inglês
Published: BioMed Central 2012
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Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3565988/
https://ncbi.nlm.nih.gov/pubmed/23234315
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-2094-9-268
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