Tet2 and Tet3 cooperate with B-lineage transcription factors to regulate DNA modification and chromatin accessibility

Ten-eleven translocation (TET) enzymes oxidize 5-methylcytosine, facilitating DNA demethylation and generating new epigenetic marks. Here we show that concomitant loss of Tet2 and Tet3 in mice at early B cell stage blocked the pro- to pre-B cell transition in the bone marrow, decreased Irf4 expressi...

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Udgivet i:eLife
Main Authors: Lio, Chan-Wang, Zhang, Jiayuan, González-Avalos, Edahí, Hogan, Patrick G, Chang, Xing, Rao, Anjana
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications, Ltd 2016
Fag:
Genes and Chromosomes
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5142813/
https://ncbi.nlm.nih.gov/pubmed/27869616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.18290
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