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High-mobility group box 1 inhibits HCO(3)(−) absorption in the medullary thick ascending limb through RAGE-Rho-ROCK-mediated inhibition of basolateral Na(+)/H(+) exchange
High-mobility group box 1 (HMGB1) is a nuclear protein released extracellularly in response to infection or injury, where it activates immune responses and contributes to the pathogenesis of kidney dysfunction in sepsis and sterile inflammatory disorders. Recently, we demonstrated that HMGB1 inhibit...
Tallennettuna:
| Julkaisussa: | Am J Physiol Renal Physiol |
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| Päätekijät: | , , , |
| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Physiological Society
2016
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5142168/ https://ncbi.nlm.nih.gov/pubmed/27358052 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00185.2016 |
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