Basolateral LPS inhibits NHE3 and HCO(3)(−) absorption through TLR4/MyD88-dependent ERK activation in medullary thick ascending limb

Sepsis is associated with defects in renal tubule function, but the underlying mechanisms are incompletely understood. Recently, we demonstrated that Gram-negative bacterial lipopolysaccharide (LPS) inhibits HCO(3)(−) absorption in the medullary thick ascending limb (MTAL) through activation of Toll...

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Detalhes bibliográficos
Main Authors: Watts, Bruns A., George, Thampi, Sherwood, Edward R., Good, David W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
Assuntos:
Membrane Transporters, Ion Channels and Pumps
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3233797/
https://ncbi.nlm.nih.gov/pubmed/21881005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpcell.00237.2011
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