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Lumen LPS inhibits HCO(3)(−) absorption in the medullary thick ascending limb through TLR4-PI3K-Akt-mTOR-dependent inhibition of basolateral Na(+)/H(+) exchange
Sepsis and endotoxemia induce defects in renal tubule function, but the mechanisms are poorly understood. Recently, we demonstrated that lipopolysaccharide (LPS) inhibits HCO(3)(−) absorption in the medullary thick ascending limb (MTAL) through activation of different Toll-like receptor 4 (TLR4) sig...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Physiological Society
2013
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3891256/ https://ncbi.nlm.nih.gov/pubmed/23698118 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00102.2013 |
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