Lumen LPS inhibits HCO(3)(−) absorption in the medullary thick ascending limb through TLR4-PI3K-Akt-mTOR-dependent inhibition of basolateral Na(+)/H(+) exchange

Sepsis and endotoxemia induce defects in renal tubule function, but the mechanisms are poorly understood. Recently, we demonstrated that lipopolysaccharide (LPS) inhibits HCO(3)(−) absorption in the medullary thick ascending limb (MTAL) through activation of different Toll-like receptor 4 (TLR4) sig...

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Hauptverfasser: Watts, Bruns A., George, Thampi, Good, David W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Physiological Society 2013
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3891256/
https://ncbi.nlm.nih.gov/pubmed/23698118
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00102.2013
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