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Cortical bone loss caused by glucocorticoid excess requires RANKL production by osteocytes and is associated with reduced OPG expression in mice

Glucocorticoid excess is a major cause of low bone mass and fractures. Glucocorticoid administration decreases cortical thickness and increases cortical porosity in mice, and these changes are associated with increased osteoclast number at the endocortical surface. Receptor activator of NF-κB ligand...

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Dades bibliogràfiques
Publicat a:Am J Physiol Endocrinol Metab
Autors principals: Piemontese, Marilina, Xiong, Jinhu, Fujiwara, Yuko, Thostenson, Jeff D., O'Brien, Charles A.
Format: Artigo
Idioma:Inglês
Publicat: American Physiological Society 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5142003/
https://ncbi.nlm.nih.gov/pubmed/27460899
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00219.2016
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