Adenovirally-Induced Polyfunctional T Cells Do Not Necessarily Recognize the Infected Target: Lessons from a Phase I Trial of the AERAS-402 Vaccine

The development of a vaccine for Mycobacterium tuberculosis (Mtb) has been impeded by the absence of correlates of protective immunity. One correlate would be the ability of cells induced by vaccination to recognize the Mtb-infected cell. AERAS-402 is a replication-deficient serotype 35 adenovirus c...

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Veröffentlicht in:Sci Rep
Hauptverfasser: Nyendak, Melissa, Swarbrick, Gwendolyn M., Duncan, Amanda, Cansler, Meghan, Huff, Ervina Winata, Hokey, David, Evans, Tom, Barker, Lewellys, Blatner, Gretta, Sadoff, Jerald, Douoguih, Macaya, Pau, Maria Grazia, Lewinsohn, Deborah A., Lewinsohn, David M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5141283/
https://ncbi.nlm.nih.gov/pubmed/27805026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36355
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