Adenovirally-Induced Polyfunctional T Cells Do Not Necessarily Recognize the Infected Target: Lessons from a Phase I Trial of the AERAS-402 Vaccine

The development of a vaccine for Mycobacterium tuberculosis (Mtb) has been impeded by the absence of correlates of protective immunity. One correlate would be the ability of cells induced by vaccination to recognize the Mtb-infected cell. AERAS-402 is a replication-deficient serotype 35 adenovirus c...

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Bibliografski detalji
Izdano u:Sci Rep
Glavni autori: Nyendak, Melissa, Swarbrick, Gwendolyn M., Duncan, Amanda, Cansler, Meghan, Huff, Ervina Winata, Hokey, David, Evans, Tom, Barker, Lewellys, Blatner, Gretta, Sadoff, Jerald, Douoguih, Macaya, Pau, Maria Grazia, Lewinsohn, Deborah A., Lewinsohn, David M.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group 2016
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Article
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5141283/
https://ncbi.nlm.nih.gov/pubmed/27805026
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep36355
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