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The Limitations of Model-Based Experimental Design and Parameter Estimation in Sloppy Systems

We explore the relationship among experimental design, parameter estimation, and systematic error in sloppy models. We show that the approximate nature of mathematical models poses challenges for experimental design in sloppy models. In many models of complex biological processes it is unknown what...

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Pubblicato in:PLoS Comput Biol
Autori principali: White, Andrew, Tolman, Malachi, Thames, Howard D., Withers, Hubert Rodney, Mason, Kathy A., Transtrum, Mark K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5140062/
https://ncbi.nlm.nih.gov/pubmed/27923060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005227
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