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The Limitations of Model-Based Experimental Design and Parameter Estimation in Sloppy Systems
We explore the relationship among experimental design, parameter estimation, and systematic error in sloppy models. We show that the approximate nature of mathematical models poses challenges for experimental design in sloppy models. In many models of complex biological processes it is unknown what...
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Publicado no: | PLoS Comput Biol |
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Main Authors: | , , , , , |
Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
Public Library of Science
2016
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5140062/ https://ncbi.nlm.nih.gov/pubmed/27923060 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005227 |
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