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The Limitations of Model-Based Experimental Design and Parameter Estimation in Sloppy Systems

We explore the relationship among experimental design, parameter estimation, and systematic error in sloppy models. We show that the approximate nature of mathematical models poses challenges for experimental design in sloppy models. In many models of complex biological processes it is unknown what...

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Detalhes bibliográficos
Publicado no:PLoS Comput Biol
Main Authors: White, Andrew, Tolman, Malachi, Thames, Howard D., Withers, Hubert Rodney, Mason, Kathy A., Transtrum, Mark K.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5140062/
https://ncbi.nlm.nih.gov/pubmed/27923060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005227
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