The Limitations of Model-Based Experimental Design and Parameter Estimation in Sloppy Systems

We explore the relationship among experimental design, parameter estimation, and systematic error in sloppy models. We show that the approximate nature of mathematical models poses challenges for experimental design in sloppy models. In many models of complex biological processes it is unknown what...

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Dades bibliogràfiques
Publicat a:PLoS Comput Biol
Autors principals: White, Andrew, Tolman, Malachi, Thames, Howard D., Withers, Hubert Rodney, Mason, Kathy A., Transtrum, Mark K.
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5140062/
https://ncbi.nlm.nih.gov/pubmed/27923060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1005227
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