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Sloppy Models, Parameter Uncertainty, and the Role of Experimental Design

Computational models are increasingly used to understand and predict complex biological phenomena. These models contain many unknown parameters, at least some of which are difficult to measure directly, and instead are estimated by fitting to time-course data. Previous work has suggested that even w...

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Detalhes bibliográficos
Main Authors: Apgar, Joshua F., Witmer, David K., White, Forest M., Tidor, Bruce
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3505121/
https://ncbi.nlm.nih.gov/pubmed/20556289
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b918098b
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