Limited sampling strategy for determining metformin area under the plasma concentration–time curve

AIM: The aim was to develop and validate limited sampling strategy (LSS) models to predict the area under the plasma concentration–time curve (AUC) for metformin. METHODS: Metformin plasma concentrations (n = 627) at 0–24 h after a single 500 mg dose were used for LSS development, based on all subse...

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Detalles Bibliográficos
Publicado en:Br J Clin Pharmacol
Main Authors: Santoro, Ana Beatriz, Stage, Tore Bjerregaard, Struchiner, Claudio José, Christensen, Mette Marie Hougaard, Brosen, Kim, Suarez‐Kurtz, Guilherme
Formato: Artigo
Idioma:Inglês
Publicado: John Wiley and Sons Inc. 2016
Assuntos:
Pharmacokinetics
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137825/
https://ncbi.nlm.nih.gov/pubmed/27324407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13049
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