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Influence of pharmacogenetic polymorphisms and demographic variables on metformin pharmacokinetics in an admixed Brazilian cohort

AIMS: To identify pharmacogenetic and demographic variables that influence the systemic exposure to metformin in an admixed Brazilian cohort. METHODS: The extreme discordant phenotype was used to select 106 data sets from nine metformin bioequivalence trials, comprising 256 healthy adults. Eleven si...

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Podrobná bibliografie
Vydáno v:Br J Clin Pharmacol
Hlavní autoři: Santoro, Ana Beatriz, Botton, Mariana Rodrigues, Struchiner, Claudio José, Suarez‐Kurtz, Guilherme
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5903234/
https://ncbi.nlm.nih.gov/pubmed/29352482
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.13522
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