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Fluorine-19 NMR and computational quantification of isoflurane binding to the voltage-gated sodium channel NaChBac
Voltage-gated sodium channels (Na(V)) play an important role in general anesthesia. Electrophysiology measurements suggest that volatile anesthetics such as isoflurane inhibit Na(V) by stabilizing the inactivated state or altering the inactivation kinetics. Recent computational studies suggested the...
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| Izdano u: | Proc Natl Acad Sci U S A |
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| Glavni autori: | , , , , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
National Academy of Sciences
2016
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5137747/ https://ncbi.nlm.nih.gov/pubmed/27856739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1609939113 |
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