Fluorine-19 NMR and computational quantification of isoflurane binding to the voltage-gated sodium channel NaChBac

Voltage-gated sodium channels (Na(V)) play an important role in general anesthesia. Electrophysiology measurements suggest that volatile anesthetics such as isoflurane inhibit Na(V) by stabilizing the inactivated state or altering the inactivation kinetics. Recent computational studies suggested the...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Kinde, Monica N., Bondarenko, Vasyl, Granata, Daniele, Bu, Weiming, Grasty, Kimberly C., Loll, Patrick J., Carnevale, Vincenzo, Klein, Michael L., Eckenhoff, Roderic G., Tang, Pei, Xu, Yan
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137747/
https://ncbi.nlm.nih.gov/pubmed/27856739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1609939113
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