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Propofol inhibits the voltage-gated sodium channel NaChBac at multiple sites

Voltage-gated sodium (Na(V)) channels are important targets of general anesthetics, including the intravenous anesthetic propofol. Electrophysiology studies on the prokaryotic Na(V) channel NaChBac have demonstrated that propofol promotes channel activation and accelerates activation-coupled inactiv...

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Foilsithe in:J Gen Physiol
Main Authors: Wang, Yali, Yang, Elaine, Wells, Marta M., Bondarenko, Vasyl, Woll, Kellie, Carnevale, Vincenzo, Granata, Daniele, Klein, Michael L., Eckenhoff, Roderic G., Dailey, William P., Covarrubias, Manuel, Tang, Pei, Xu, Yan
Formáid: Artigo
Teanga:Inglês
Foilsithe: Rockefeller University Press 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6122922/
https://ncbi.nlm.nih.gov/pubmed/30018039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201811993
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