Propofol inhibits the voltage-gated sodium channel NaChBac at multiple sites

Voltage-gated sodium (Na(V)) channels are important targets of general anesthetics, including the intravenous anesthetic propofol. Electrophysiology studies on the prokaryotic Na(V) channel NaChBac have demonstrated that propofol promotes channel activation and accelerates activation-coupled inactiv...

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Detalhes bibliográficos
Publicado no:J Gen Physiol
Main Authors: Wang, Yali, Yang, Elaine, Wells, Marta M., Bondarenko, Vasyl, Woll, Kellie, Carnevale, Vincenzo, Granata, Daniele, Klein, Michael L., Eckenhoff, Roderic G., Dailey, William P., Covarrubias, Manuel, Tang, Pei, Xu, Yan
Formato: Artigo
Idioma:Inglês
Publicado em: Rockefeller University Press 2018
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6122922/
https://ncbi.nlm.nih.gov/pubmed/30018039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201811993
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