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Fluorine-19 NMR and computational quantification of isoflurane binding to the voltage-gated sodium channel NaChBac
Voltage-gated sodium channels (Na(V)) play an important role in general anesthesia. Electrophysiology measurements suggest that volatile anesthetics such as isoflurane inhibit Na(V) by stabilizing the inactivated state or altering the inactivation kinetics. Recent computational studies suggested the...
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| Publié dans: | Proc Natl Acad Sci U S A |
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| Auteurs principaux: | , , , , , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
National Academy of Sciences
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5137747/ https://ncbi.nlm.nih.gov/pubmed/27856739 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1609939113 |
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