Fluorine-19 NMR and computational quantification of isoflurane binding to the voltage-gated sodium channel NaChBac

Voltage-gated sodium channels (Na(V)) play an important role in general anesthesia. Electrophysiology measurements suggest that volatile anesthetics such as isoflurane inhibit Na(V) by stabilizing the inactivated state or altering the inactivation kinetics. Recent computational studies suggested the...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:Proc Natl Acad Sci U S A
Päätekijät: Kinde, Monica N., Bondarenko, Vasyl, Granata, Daniele, Bu, Weiming, Grasty, Kimberly C., Loll, Patrick J., Carnevale, Vincenzo, Klein, Michael L., Eckenhoff, Roderic G., Tang, Pei, Xu, Yan
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: National Academy of Sciences 2016
Aiheet:
Biological Sciences
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137747/
https://ncbi.nlm.nih.gov/pubmed/27856739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1609939113
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