Fluorine-19 NMR and computational quantification of isoflurane binding to the voltage-gated sodium channel NaChBac

Voltage-gated sodium channels (Na(V)) play an important role in general anesthesia. Electrophysiology measurements suggest that volatile anesthetics such as isoflurane inhibit Na(V) by stabilizing the inactivated state or altering the inactivation kinetics. Recent computational studies suggested the...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Proc Natl Acad Sci U S A
Egile Nagusiak: Kinde, Monica N., Bondarenko, Vasyl, Granata, Daniele, Bu, Weiming, Grasty, Kimberly C., Loll, Patrick J., Carnevale, Vincenzo, Klein, Michael L., Eckenhoff, Roderic G., Tang, Pei, Xu, Yan
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: National Academy of Sciences 2016
Gaiak:
Biological Sciences
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137747/
https://ncbi.nlm.nih.gov/pubmed/27856739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1609939113
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