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Isoflurane modulates activation and inactivation gating of the prokaryotic Na(+) channel NaChBac

Voltage-gated Na(+) channels (Na(v)) have emerged as important presynaptic targets for volatile anesthetic (VA) effects on synaptic transmission. However, the detailed biophysical mechanisms by which VAs modulate Na(v) function remain unclear. VAs alter macroscopic activation and inactivation of the...

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Detalhes bibliográficos
Publicado no:J Gen Physiol
Main Authors: Sand, Rheanna M., Gingrich, Kevin J., Macharadze, Tamar, Herold, Karl F., Hemmings, Hugh C.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5460948/
https://ncbi.nlm.nih.gov/pubmed/28416648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201611600
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