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The multifaceted influence of histone deacetylases on DNA damage signalling and DNA repair

Histone/protein deacetylases play multiple roles in regulating gene expression and protein activation and stability. Their deregulation during cancer initiation and progression cause resistance to therapy. Here, we review the role of histone deacetylases (HDACs) and the NAD(+) dependent sirtuins (SI...

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Bibliographic Details
Published in:Nucleic Acids Res
Main Authors: Roos, Wynand Paul, Krumm, Andrea
Format: Artigo
Language:Inglês
Published: Oxford University Press 2016
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5137451/
https://ncbi.nlm.nih.gov/pubmed/27738139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkw922
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