Histone deacetylase inhibitors as radiosensitisers: effects on DNA damage signalling and repair

Many cancers display increased expression of histone deacetylases (HDACs) and therefore transcriptionally inactive chromatin, resulting in the downregulation of genes including tumour suppressor and DNA repair genes. Histone deacetylase inhibitors (HDACi) are a heterogeneous group of epigenetic ther...

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Main Authors: Groselj, B, Sharma, N L, Hamdy, F C, Kerr, M, Kiltie, A E
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2013
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3590661/
https://ncbi.nlm.nih.gov/pubmed/23361058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2013.21
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