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Histone Deacetylase Regulation of ATM-Mediated DNA Damage Signaling
Ataxia-telangiectasia mutated (ATM) is a major regulator of the DNA damage response. ATM promotes the activation of BRCA1, CHK2, and p53 leading to the induction of response genes such as CDKN1A (p21), GADD45A and RRM2B that promote cell cycle arrest and DNA repair. The up-regulation of these respon...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3821775/ https://ncbi.nlm.nih.gov/pubmed/23939379 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-12-1242 |
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