Epigallocatechin-3-Gallate Accelerates Relaxation and Ca(2+) Transient Decay and Desensitizes Myofilaments in Healthy and Mybpc3-Targeted Knock-in Cardiomyopathic Mice

Background: Hypertrophic cardiomyopathy (HCM) is the most common inherited cardiac muscle disease with left ventricular hypertrophy, interstitial fibrosis and diastolic dysfunction. Increased myofilament Ca(2+) sensitivity could be the underlying cause of diastolic dysfunction. Epigallocatechin-3-ga...

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Bibliographic Details
Published in:Front Physiol
Main Authors: Friedrich, Felix W., Flenner, Frederik, Nasib, Mahtab, Eschenhagen, Thomas, Carrier, Lucie
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2016
Subjects:
Physiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5136558/
https://ncbi.nlm.nih.gov/pubmed/27994558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphys.2016.00607
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