Intrinsic aggregation propensity of the p63 and p73 TI domains correlates with p53R175H interaction and suggests further significance of aggregation events in the p53 family

The high percentage of p53 missense mutations found in cancer has been attributed to mutant acquired oncogenic gain of functions. Different aspects of these tumour-promoting functions are caused by repression of the transcriptional activity of p53 family members p63 and p73. A subset of frequently o...

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Detalles Bibliográficos
Publicado en:Cell Death Differ
Main Authors: Kehrloesser, Sebastian, Osterburg, Christian, Tuppi, Marcel, Schäfer, Birgit, Vousden, Karen Heather, Dötsch, Volker
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 2016
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Original Paper
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5136486/
https://ncbi.nlm.nih.gov/pubmed/27447112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2016.75
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