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Functional interplay between MDM2, p63/p73 and mutant p53

Many cancers express mutant p53 proteins that have lost wild-type tumor suppressor activity and, in many cases, have acquired oncogenic functions that can contribute to tumor progression. These activities of mutant p53 reflect interactions with several other proteins, including the p53 family member...

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Détails bibliographiques
Publié dans:Oncogene
Auteurs principaux: Stindt, M H, Muller, P A J, Ludwig, R L, Kehrloesser, S, Dötsch, V, Vousden, K H
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2015
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4351904/
https://ncbi.nlm.nih.gov/pubmed/25417702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2014.359
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