Intrinsic aggregation propensity of the p63 and p73 TI domains correlates with p53R175H interaction and suggests further significance of aggregation events in the p53 family

The high percentage of p53 missense mutations found in cancer has been attributed to mutant acquired oncogenic gain of functions. Different aspects of these tumour-promoting functions are caused by repression of the transcriptional activity of p53 family members p63 and p73. A subset of frequently o...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Death Differ
Egile Nagusiak: Kehrloesser, Sebastian, Osterburg, Christian, Tuppi, Marcel, Schäfer, Birgit, Vousden, Karen Heather, Dötsch, Volker
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group 2016
Gaiak:
Original Paper
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC5136486/
https://ncbi.nlm.nih.gov/pubmed/27447112
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2016.75
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