Regression of chemotherapy-resistant Polymerase ε (POLE) ultra-mutated and MSH6 hyper-mutated endometrial tumors with nivolumab

PURPOSE: The management of endometrial carcinoma no longer amenable to treatment with surgery or radiation has not improved significantly with modern chemotherapy. Alternative therapeutic options are desperately needed. EXPERIMENTAL DESIGN: We describe 2 heavily pretreated patients with recurrent di...

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Veröffentlicht in:Clin Cancer Res
Hauptverfasser: Santin, Alessandro D., Bellone, Stefania, Buza, Natalia, Choi, Jungmin, Schwartz, Peter E., Schlessinger, Joseph, Lifton, Richard P.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135588/
https://ncbi.nlm.nih.gov/pubmed/27486176
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-16-1031
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