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Polymerase ε (POLE) mutations in endometrial cancer: clinical outcomes and implications for Lynch Syndrome testing
BACKGROUND: DNA polymerase epsilon (POLE) exonuclease domain mutations characterize a subtype of endometrial cancer (EC) with markedly increased somatic mutational burden. POLE mutant tumors were described as a molecular subtype with improved progression-free survival (PFS) by The Cancer Genome Atla...
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| Publicado no: | Cancer |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4304930/ https://ncbi.nlm.nih.gov/pubmed/25224212 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.29046 |
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