Polymerase ε (POLE) mutations in endometrial cancer: clinical outcomes and implications for Lynch Syndrome testing

BACKGROUND: DNA polymerase epsilon (POLE) exonuclease domain mutations characterize a subtype of endometrial cancer (EC) with markedly increased somatic mutational burden. POLE mutant tumors were described as a molecular subtype with improved progression-free survival (PFS) by The Cancer Genome Atla...

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Vydáno v:Cancer
Hlavní autoři: Billingsley, Caroline C, Cohn, David E, Mutch, David G, Stephens, Julie A, Suarez, Adrian A, Goodfellow, Paul J
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4304930/
https://ncbi.nlm.nih.gov/pubmed/25224212
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.29046
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