Polymerase ε (POLE) ultra-mutated tumors induce robust tumor-specific CD4+ T cell responses in endometrial cancer patients

OBJECTIVE: Around 7–10% of endometrial carcinomas are characterized by Polymerase-ε-(POLE) exonuclease-domain-mutations, an ultra-mutated-phenotype and a favorable prognosis. It is currently unknown whether POLE ultra-mutated-tumors are more immunogenic when compared to the other groups of endometri...

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Detalhes bibliográficos
Publicado no:Gynecol Oncol
Main Authors: Bellone, Stefania, Centritto, Floriana, Black, Jonathan, Schwab, Carlton, English, Diana, Cocco, Emiliano, Lopez, Salvatore, Bonazzoli, Elena, Predolini, Federica, Ferrari, Francesca, Silasi, Dan-Arin, Ratner, Elena, Azodi, Masoud, Schwartz, Peter E., Santin, Alessandro D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4469551/
https://ncbi.nlm.nih.gov/pubmed/25931171
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2015.04.027
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