Polymerase ε (POLE) ultra-mutation in uterine tumors correlates with T lymphocyte infiltration and increased resistance to platinum-based chemotherapy in vitro

OBJECTIVE: Up to 12 % of all endometrial-carcinomas (EC) harbor DNA-polymerase-ε-(POLE) mutations. It is currently unknown whether the favorable prognosis of POLE-mutated EC is derived from their low metastatic capability, extraordinary number of somatic mutations thus imparting immunogenicity, or a...

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Publicado no:Gynecol Oncol
Main Authors: Bellone, Stefania, Eliana, Bignotti, Lonardi, Silvia, Ferrari, Francesca, Centritto, Floriana, Masserdotti, Alice, Pettinella, Francesca, Black, Jonathan, Menderes, Gulden, Altwerger, Gary, Hui, Pei, Lopez, Salvatore, de Haydu, Christopher, Bonazzoli, Elena, Predolini, Federica, Zammataro, Luca, Cocco, Emiliano, Ferrari, Federico, Ravaggi, Antonella, Romani, Chiara, Facchettie, Fabio, Sartori, Enrico, Odicino, Franco E., Silasi, Dan-Arin, Litkouhi, Babak, Ratner, Elena, Azodi, Masoud, Schwartz, Peter E., Santin, Alessandro D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5183545/
https://ncbi.nlm.nih.gov/pubmed/27894751
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ygyno.2016.11.023
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