Recognition of the 3′ splice site RNA by the U2AF heterodimer involves a dynamic population shift

An essential early step in the assembly of human spliceosomes onto pre-mRNA involves the recognition of regulatory RNA cis elements in the 3′ splice site by the U2 auxiliary factor (U2AF). The large (U2AF65) and small (U2AF35) subunits of the U2AF heterodimer contact the polypyrimidine tract (Py-tra...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Voith von Voithenberg, Lena, Sánchez-Rico, Carolina, Kang, Hyun-Seo, Madl, Tobias, Zanier, Katia, Barth, Anders, Warner, Lisa R., Sattler, Michael, Lamb, Don C.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2016
Matèries:
PNAS Plus
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135374/
https://ncbi.nlm.nih.gov/pubmed/27799531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1605873113
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