An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2

The recognition of cis-regulatory RNA motifs in human transcripts by RNA binding proteins (RBPs) is essential for gene regulation. The molecular features that determine RBP specificity are often poorly understood. Here, we combined NMR structural biology with high-throughput iCLIP approaches to iden...

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Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Kang, Hyun-Seo, Sánchez-Rico, Carolina, Ebersberger, Stefanie, Sutandy, F. X. Reymond, Busch, Anke, Welte, Thomas, Stehle, Ralf, Hipp, Clara, Schulz, Laura, Buchbender, Andreas, Zarnack, Kathi, König, Julian, Sattler, Michael
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2020
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7132250/
https://ncbi.nlm.nih.gov/pubmed/32188783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1913483117
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