An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2

The recognition of cis-regulatory RNA motifs in human transcripts by RNA binding proteins (RBPs) is essential for gene regulation. The molecular features that determine RBP specificity are often poorly understood. Here, we combined NMR structural biology with high-throughput iCLIP approaches to iden...

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Foilsithe in:Proc Natl Acad Sci U S A
Main Authors: Kang, Hyun-Seo, Sánchez-Rico, Carolina, Ebersberger, Stefanie, Sutandy, F. X. Reymond, Busch, Anke, Welte, Thomas, Stehle, Ralf, Hipp, Clara, Schulz, Laura, Buchbender, Andreas, Zarnack, Kathi, König, Julian, Sattler, Michael
Formáid: Artigo
Teanga:Inglês
Foilsithe: National Academy of Sciences 2020
Ábhair:
Biological Sciences
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7132250/
https://ncbi.nlm.nih.gov/pubmed/32188783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1913483117
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