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An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2
The recognition of cis-regulatory RNA motifs in human transcripts by RNA binding proteins (RBPs) is essential for gene regulation. The molecular features that determine RBP specificity are often poorly understood. Here, we combined NMR structural biology with high-throughput iCLIP approaches to iden...
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| Gepubliceerd in: | Proc Natl Acad Sci U S A |
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| Hoofdauteurs: | , , , , , , , , , , , , |
| Formaat: | Artigo |
| Taal: | Inglês |
| Gepubliceerd in: |
National Academy of Sciences
2020
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| Onderwerpen: | |
| Online toegang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7132250/ https://ncbi.nlm.nih.gov/pubmed/32188783 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1913483117 |
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