An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2

The recognition of cis-regulatory RNA motifs in human transcripts by RNA binding proteins (RBPs) is essential for gene regulation. The molecular features that determine RBP specificity are often poorly understood. Here, we combined NMR structural biology with high-throughput iCLIP approaches to iden...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Kang, Hyun-Seo, Sánchez-Rico, Carolina, Ebersberger, Stefanie, Sutandy, F. X. Reymond, Busch, Anke, Welte, Thomas, Stehle, Ralf, Hipp, Clara, Schulz, Laura, Buchbender, Andreas, Zarnack, Kathi, König, Julian, Sattler, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2020
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7132250/
https://ncbi.nlm.nih.gov/pubmed/32188783
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1913483117
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