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Structural and functional consequences of a disease mutation in the telomere protein TPP1
Telomerase replicates chromosome ends to facilitate continued cell division. Mutations that compromise telomerase function result in stem cell failure diseases, such as dyskeratosis congenita (DC). One such mutation (K170Δ), residing in the telomerase-recruitment factor TPP1, provides an excellent o...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5135350/ https://ncbi.nlm.nih.gov/pubmed/27807141 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1605685113 |
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