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Combining conservation and species-specific differences to determine how human telomerase binds telomeres

Telomerase catalyzes telomeric DNA synthesis at chromosome ends to allow for continued cell division. The telomeric protein TPP1 is essential for enhancing the processivity of telomerase and recruiting the enzyme to telomeres. The telomerase interaction surface on human TPP1 has been mapped to 2 reg...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Proc Natl Acad Sci U S A
Main Authors: Tesmer, Valerie M., Smith, Eric M., Danciu, Oana, Padmanaban, Shilpa, Nandakumar, Jayakrishnan
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2019
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6936698/
https://ncbi.nlm.nih.gov/pubmed/31822618
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1911912116
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