Tristetraprolin Down-Regulation Contributes to Persistent TNF-Alpha Expression Induced by Cigarette Smoke Extract through a Post-Transcriptional Mechanism

RATIONALE: Tumor necrosis factor-alpha (TNF-α) is a potent pro-inflammatory mediator and its expression is up-regulated in chronic obstructive pulmonary disease (COPD). Tristetraprolin (TTP) is implicated in regulation of TNF-α expression; however, whether TTP is involved in cigarette smoke-induced...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Zhao, Xue-Ke, Che, Pulin, Cheng, Ming-Liang, Zhang, Quan, Mu, Mao, Li, Hong, Luo, Yuan, Liang, Yue-Dong, Luo, Xin-Hua, Gao, Chang-Qing, Jackson, Patricia L., Wells, J. Michael, Zhou, Yong, Hu, Meng, Cai, Guoqiang, Thannickal, Victor J., Steele, Chad, Blalock, J. Edwin, Han, Xiaosi, Chen, Ching-Yi, Ding, Qiang
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5135108/
https://ncbi.nlm.nih.gov/pubmed/27911957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0167451
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