A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1

Inhibition or genetic deletion of poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) is protective against toxic insults in many organ systems. The molecular mechanisms underlying PARP-1–dependent cell death involve release of mitochondrial apoptosis-inducing factor (AIF) and its translocation to the nucl...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Science
Main Authors: Wang, Yingfei, An, Ran, Umanah, George K., Park, Hyejin, Nambiar, Kalyani, Eacker, Stephen M., Kim, BongWoo, Bao, Lei, Harraz, Maged M., Chang, Calvin, Chen, Rong, Wang, Jennifer E., Kam, Tae-In, Jeong, Jun Seop, Xie, Zhi, Neifert, Stewart, Qian, Jiang, Andrabi, Shaida A., Blackshaw, Seth, Zhu, Heng, Song, Hongjun, Ming, Guo-li, Dawson, Valina L., Dawson, Ted M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5134926/
https://ncbi.nlm.nih.gov/pubmed/27846469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aad6872
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados