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Impact of Renal Impairment on the Pharmacokinetics of Apremilast and Metabolite M12
The pharmacokinetics of apremilast and its major metabolite M12 were evaluated in subjects with varying degrees of renal impairment. Men and women with renal impairment (estimated glomerular filtration rate, 60‒89 mL/min [mild, n = 8], 30‒59 mL/min [moderate, n = 8], or <30 mL/min [severe, n = 8]...
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| Publicado no: | Clin Pharmacol Drug Dev |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5132082/ https://ncbi.nlm.nih.gov/pubmed/27870479 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cpdd.256 |
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