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The impact of co-administration of ketoconazole and rifampicin on the pharmacokinetics of apremilast in healthy volunteers

AIMS: Two clinical studies were conducted to determine possible drug−drug interactions between apremilast and a strong CYP3A4 inhibitor, ketoconazole, or a potent CYP3A4 inducer, rifampicin. The main objectives of these two studies were to evaluate the impact of multiple doses of ketoconazole on the...

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Detalhes bibliográficos
Publicado no:Br J Clin Pharmacol
Main Authors: Liu, Yong, Zhou, Simon, Wan, Yuntao, Wu, Anfan, Palmisano, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4238785/
https://ncbi.nlm.nih.gov/pubmed/24962564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bcp.12448
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