The effects of apremilast on the QTc interval in healthy male volunteers: a formal, thorough QT study

Objective: This study was conducted to evaluate the effect of apremilast and its major metabolites on the placebo-corrected change-from-baseline QTc interval of an electrocardiogram (ECG). Materials and methods: Healthy male subjects received each of 4 treatments in a randomized, crossover manner. I...

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Vydáno v:Int J Clin Pharmacol Ther
Hlavní autoři: Palmisano, Maria, Wu, Anfan, Assaf, Mahmoud, Liu, Liangang, Park, C. Hyung, Savant, Ishani, Liu, Yong, Zhou, Simon
Médium: Artigo
Jazyk:Inglês
Vydáno: Dustri-Verlag Dr. Karl Feistle 2016
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4949396/
https://ncbi.nlm.nih.gov/pubmed/27285466
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.5414/CP202555
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