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Epigenetic regulation of intestinal stem cells by Tet1-mediated DNA hydroxymethylation

Methylated cytosines are associated with gene silencing. The ten-eleven translocation (TET) hydroxylases, which oxidize methylated cytosines to 5-hydroxymethylcytosine (5hmC), are essential for cytosine demethylation. Gene silencing and activation are critical for intestinal stem cell (ISC) maintena...

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Détails bibliographiques
Publié dans:Genes Dev
Auteurs principaux: Kim, Rinho, Sheaffer, Karyn L., Choi, Inchan, Won, Kyoung-Jae, Kaestner, Klaus H.
Format: Artigo
Langue:Inglês
Publié: Cold Spring Harbor Laboratory Press 2016
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5131782/
https://ncbi.nlm.nih.gov/pubmed/27856615
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.288035.116
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