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DNA hypomethylation contributes to genomic instability and intestinal cancer initiation

Intestinal cancer is a heterogeneous disease driven by genetic mutations and epigenetic changes. Approximately 80% of sporadic colorectal cancers are initiated by mutation and inactivation of the adenomatous polyposis coli (APC) gene, which results in unrestrained intestinal epithelial growth and fo...

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Detalhes bibliográficos
Publicado no:Cancer Prev Res (Phila)
Main Authors: Sheaffer, Karyn L., Elliott, Ellen N., Kaestner, Klaus H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4930698/
https://ncbi.nlm.nih.gov/pubmed/26883721
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1940-6207.CAPR-15-0349
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