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Collecting duct-specific knockout of nitric oxide synthase 3 impairs water excretion in a sex-dependent manner
Nitric oxide (NO) inhibits collecting duct (CD) Na(+) and water reabsorption. Mice with CD-specific knockout (KO) of NO synthase 1 (NOS1) have salt-sensitive hypertension. In contrast, the role of NOS3 in CD salt and water reabsorption is unknown. Mice with CD NOS3 KO were generated with loxP-flanke...
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| Publicado en: | Am J Physiol Renal Physiol |
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| Autores principales: | , , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
American Physiological Society
2016
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5130459/ https://ncbi.nlm.nih.gov/pubmed/27707708 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00494.2016 |
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