Collecting duct-specific knockout of renin attenuates angiotensin II-induced hypertension

The physiological and pathophysiological significance of collecting duct (CD)-derived renin, particularly as it relates to blood pressure (BP) regulation, is unknown. To address this question, we generated CD-specific renin knockout (KO) mice and examined BP and renal salt and water excretion. Mice...

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Autori principali: Ramkumar, Nirupama, Stuart, Deborah, Rees, Sara, Hoek, Alfred Van, Sigmund, Curt D., Kohan, Donald E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2014
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4200300/
https://ncbi.nlm.nih.gov/pubmed/25122048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00367.2014
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