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Collecting duct-derived endothelin regulates arterial pressure and Na excretion via nitric oxide
Mice with collecting duct-specific deletion of endothelin-1 are hypertensive and have impaired Na excretion. Since endothelin-1 activates nitric oxide synthase (NOS) in collecting duct, we hypothesized that impaired renal NO production in knockout mice exacerbates the hypertensive state. Control and...
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| Hlavní autoři: | , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2008
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3799791/ https://ncbi.nlm.nih.gov/pubmed/18391099 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/HYPERTENSIONAHA.107.108126 |
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