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Nephron‐Specific Disruption of Nitric Oxide Synthase 3 Causes Hypertension and Impaired Salt Excretion
BACKGROUND: In vitro studies suggest that nephron nitric oxide synthase 3 (NOS3) modulates tubule Na(+) transport. METHODS AND RESULTS: To assess nephron NOS3 relevance in vivo, knockout (KO) mice with doxycycline‐inducible nephron‐wide deletion of NOS3 were generated. During 1 week of salt loading,...
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| Publicado en: | J Am Heart Assoc |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
John Wiley and Sons Inc.
2018
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6064857/ https://ncbi.nlm.nih.gov/pubmed/29997131 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.118.009236 |
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